Where is the Innovation?
- Undenatured collagen is a proven ingredient to induce immune tolerance & thereby alleviate joint inflammation
- NT-II is uniquely sourced from premium Atlantic Salmon with no processing or purification
- Part of a fully circular economic business model where 100% of the salmon is utilized
- Proprietary production process is gentle and muted temperatures that ensures the type II collagen remains in its natural undenatured state
- Joint Health is a universal problem with limited options but still hasahigh demand growth of 7 – 9% globally/year
What Is NT-II
- NT-II is a completely natural product, rich in undenatured type-II collagen
- >25% total collagen content
- >19% natural (undenatured) type II collagen
- The soluble undenatured type II collagen is contained and protected in a natural calcium hydroxyapatite scaffold Rich in trace minerals like phosphorous (>9%) and zinc
- Supporting joint health to help maintain and improve activity levels including daily step targets which are essential for healthy aging
NT-II : Specification example
Mechanism of action for Immune Tolerance
- NT-II is taken up by M cells into the Peyer’s patch
- Dendritic cells recognize the soluble type II undenatured collagen as ‘belonging to self’ i.e. harmless
- Active dendritic cells drive the development of regulatory T-cells (cells that protect against immune overactivity)
- Regulatory T-Cells enter the bloodstream and reach the joints, where they instigate anti-inflammatory effects including the release of IL-10 and TGF
- This reduces joint aches and stiffness and sets up an environment for healing
- Wear and tear in the joint results in undenatured type II collagen fibers being exposed outside the articular cartilage matrix
- The immune system mistakenly recognizes the type II collagen as ‘foreign’ and initiates a cascade of inflammation to remove the collagen fibers
- This results in joint stiffness and pain and underlying progressive joint damage
- KEY: NT-II re-educates the body to be tolerant to undenatured type II collagen in the joint cartilage
Joint Health Clinical Study:
A 6-month study was conducted on 26 subjects to assess the impact of 2g of NT-II on knee and hip pain and stiffness resulting from osteoarthritis (OA).
The primary endpoint was WOMAC Osteoarthritis index, a highly validated self administered methodology.
See the full poster on Natural Undenatured Type II Collagen here
(click the picture to download the poster)
Source: MAGNESIA, brochure Natural Undenatured Type II Collagen
