Abstract
Absorption, distribution, metabolism, excretion, and toxicity (ADMET) are important quality parameters for drug discovery. Allopathic drugs often exhibit side effects in later stages due to chemicals used in the pharmaceuticals. Nutraceuticals have contributed benefits in the recent era to overcome the toxicity of chemical formulations in pharmaceuticals and find an alternative path for medication in several health illnesses. Nutraceuticals are food-based supplements derived from the parts of plants (herbs, essential oils, leaves, flowers), animals (fish and egg), and even from microorganisms (Lactobacillus sp., Streptococcus thermophiles, yeast).
Curd, cheese, butter, and yeast are traditional nutraceuticals, whereas modern nutraceuticals include converting animal fats and protein into gummies and capsules. Modern nutraceuticals have recently been found as an excellent delivery vehicle for drugs in the human body based on their absorption and distribution properties. In this context, the different types of lipid nanoparticles have been recently explored for their potential application in nutraceutical delivery. This chapter emphasizes the recent advancements, the state-of-the-art lipid nanoparticles, and their applications in nutraceuticals and drug delivery.
The variety of lipid nanoparticle formulations including solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), liposomes, micelles, and nanogels along with different bioactive compounds such as curcumin, phytosterol, lauric acid, zeaxanthin, linoleic acid, cocoa butter, β-carotene, sulforaphane (SFN), hen egg-white lysozymes (HEWL), chuanxiong essential oils (CXEO), 5-demethylnobiletin (5-DN), quercetin, α-lactalbumin (ALA), casein/pea protein, acylated rapeseed protein isolate (ARPI), and duck egg-white nanogels (DEWN)/κ-carrageenan (CAR) have been highlighted toward exploring in nutraceutical delivery systems.
The significant properties of the bioactive compounds concerning the nutraceutical drug delivery systems, such as encapsulation efficiency, loading capacity, particle stability, and bioavailability, have been discussed.
Read more here
Al Huq, M.S., Mubarak, S., Srinivasan, P. (2025). Lipid Nanoparticles for Nutraceutical Delivery Systems. In: Mallakpour, S., Hussain, C.M. (eds) Handbook of Nanofillers. Springer, Singapore. https://doi.org/10.1007/978-981-96-2407-2_86
